New reagents. VIII. Reagents for protection and deprotection. TMSX(X=OTf,Br,I) as deprotecting reagents for peptide synthesis.

NOVEL REAGENTS FOR CREATINE KINASE

The purpose of this investigation was to develop a simple colorimetric method for creatine kinase (CK). The new method is based on the reaction of creatine, formed enzymatically from creatine phosphate and ADP, with different glyoxal compounds. Hydrated glyoxals, such as para-nitrophenyl, 2-thiophene, 4- biphenyl, 4, 4' -biphenyl,α-naphthyl, β-naphthyl, para-chlorophenyl, and styryl were...

Dudley Benzylation Reagent Trichloroacetimidate Reagents (2-trimethylsilyl)- Ethanesulfonyl Reagents Ethynylnaphthalenes Fluorous Protecting Groups Common Reagents for Protection Common Reagents for Deprotection

Coordinating anions: (phosphino)tetraphenylborate ligands as new reagents for synthesis.

Anionic, electron-releasing phosphines that incorporate a borate counteranion within the ligand framework are promising reagents for organometallic catalysis. This report describes the synthesis of a new class of monodentate tertiary phosphines built upon the commonly employed tetraphenylborate anion. These new phosphines are highly stable and strongly electron-releasing and readily coordinate ...

Enzymes as reagents in peptide synthesis: enzyme-labile protection for carboxyl groups.

N-Benzyloxycarbonyl derivatives of isoglutamine and isoasparagine were coupled with arginine methyl ester through the action of dicyclohexylcarbodiimide. The resulting benzyloxycarbonyl derivatives of isoglutaminylarginine methyl ester and isoasparaginylarginine methyl ester were treated with trypsin for removal of the ester groups and then with porcine pancreatic carboxypeptidase B for liberat...

Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?

The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines; however, the efficiency of the reaction could be affected by side reactions and by-product formation. Several aspects have to be taken into considera...